PET/MRI and PET/CT in Diagnosing Younger Patients With Cancer

Case Comprehensive Cancer Center (Case CCC)

Status

Completed

Conditions

Childhood Cancer

Treatments

Procedure: magnetic resonance imaging

Procedure: computed tomography

Procedure: positron emission tomography

Radiation: fludeoxyglucose F 18

Study type

Interventional

Funder types

Other

NIH

Identifiers

NCT02287636

P30CA043703 (U.S. NIH Grant/Contract)

CASE 1Z13 (Other Identifier)

CASE1Z13

NCI-2014-00828 (Registry Identifier)

Details and patient eligibility

About

This pilot clinical trial studies how well positron emission tomography (PET)/magnetic resonance imaging (MRI) works compared to PET/computed tomography (CT) in diagnosing younger patients with cancer. PET/MRI and PET/CT are procedures that combine the pictures from a PET scan and an MRI scan or a CT scan. The PET and MRI scans or PET and CT scans are done at the same time with the same machine. The combined scans give more detailed pictures of areas inside the body than either scan gives by itself. It is not yet known whether PET/MRI works better than PET/CT in diagnosing younger patients with cancer.

Full description

PRIMARY OBJECTIVES:

I. Determine the diagnostic accuracy of PET/MRI as compared to the standard of reference PET/CT in lesion detection and lesion characterization.

SECONDARY OBJECTIVES:

I. Obtain quantitative measurements in various body regions of standardized uptake values (SUV) in normal tissue and foci of pathologic tracer uptake in PET/MRI of pediatric patients with oncologic disease using various magnetic resonance attenuation correction (MRAC) methods and compare those to respective SUV based on CT attenuation correction.

II. Assess the potential for radiation dose reduction with PET/MRI when eliminating CT radiation dose.

III. Assess time efforts and workflow improvement with PET/MRI compared to sequential PET/CT plus MRI.

OUTLINE:

Patients undergo fludeoxyglucose F 18 PET/CT followed by PET/MRI.

Enrollment

13 patients

Sex

All

Ages

Under 17 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Patients who are referred by their physician for clinically indicated diagnostic fludeoxyglucose F 18 (18F-FDG) PET/CT (with or without clinically indicated diagnostic MRI)
Subjects with malignancies including hematologic disorders
Subjects NOT requiring sedation or anesthesia
Stable physical medical conditions (patients conscious and comfortable, scheduled for an elective diagnostic imaging)

Exclusion criteria

Subjects who are unable or unwilling to give their assent to both examinations if > 7 years old
Subjects requiring general anesthesia or sedation in order to undergo PET/CT or MRI
Subjects unable to undergo magnetic resonance (MR) scanning due to exclusion by University Hospitals-Case Medical Center restriction policies for Magnetic Resonance Imaging (UHCMC MRI restriction policies) as mentioned in the standard UHCMC MRI informed consent form
Previously known allergies against MRI contrast agents (exclusion criterion only for contrast enhanced MRI)
Pregnant or breast feeding subjects, as determined by standard questionnaire administered prior to scanning