PET - PEEP by EIT for Acute Respiratory Distress Syndrome Trial

Chinese Academy of Medical Sciences & Peking Union Medical College

Status: Enrolling

Conditions: ARDS, Human

Treatments: Other: Table-guided PEEP; Other: EIT-guided PEEP

Study type: Interventional

Funder types: Other

Identifiers

NCT05307913

PEEP by EIT for ARDS

Details and patient eligibility

About

This study is a multicentric randomized controlled study.The objective of this study is to compare the prognosis of patients with ARDS between EIT-oriented individualized PEEP and traditional lower PEEP/FiO2 table-oriented PEEP strategy.

Enrollment: 680 estimated patients

Sex: All

Ages: 18 to 90 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

Intubated, mechanically ventilated patients with diagnosis of ARDS according to ARDS Berlin standard by attending doctor

Exclusion criteria

1. Age < 18 years old and > 90 years old;
2. Pregnancy;
3. EIT contradictions (presence of pacemaker or automatic implantable cardioverter defibrillator);
4. Severe intracranial hypertension;
5. Pneumothorax, pneumomediastinum, subcutaneous emphysema or at high-risk for pneumothorax (e.g., pneumatocele, interstitial lung disease);
6. Unstable hemodynamic status intorerable to lung recruitment and PEEP titration, judged by an attending intensivist; (This may be a transient criterion, since patients meeting this criterion might be included later if hemodynamics improves)
7. End status of disease;
8. Patients or their families refused to participate in the study

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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680 participants in 2 patient groups

EIT-guided PEEP

Experimental group

Description:

PEEP titration by EIT

Treatment:

Other: EIT-guided PEEP

Table-guided PEEP

Active Comparator group

Description:

PEEP selection by the lower PEEP/FiO2 table

Treatment:

Other: Table-guided PEEP