Pethidine Analgesia on Labor Duration

Kanuni Sultan Suleyman Training and Research Hospital

Status: Completed

Conditions: Labor Pain

Treatments: Drug: pethidine; Drug: Placebo - Concentrate

Study type: Observational

Funder types: Other

Identifiers

NCT03882814

2018.37

Details and patient eligibility

About

Although opioid analgesics are used to treat labor pain, there are still concerns about their side effects.

The researchers in this study; aimed to evaluate the effect of pethidine on active phase duration of labor, labor pain and maternal-neonatal.

50 mg pethidine will be administered intramuscularly to the cases to be included in the study group. The patients in the control group will be given placebo injections.

Vital signs of all cases included in the study will be checked at 0, 5, 15, 30, 45 and 60 minutes. Pain will also be assessed by Visual Analogue Scale (VAS) before injection and at the 1st and 2nd hour after injection. Delivery times, maternal side effects, neonatal apgar scores and fetal findings will be recorded.

Enrollment: 240 patients

Sex: Female

Ages: 18 to 40 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• nullipar-multiparous patients;
• singleton pregnancies 37- 41 weeks (by the last menstrual period).

Exclusion criteria

• maternal respiratory rate < 8 /min,
• maternal bradycardia (<60 bpm),
• major fetal congenital anomalies,
• uterine scar presence from previous pregnancies,
• malpresentation,
• antepartum hemorrhage,
• multiple pregnancy,
• labor induction,
• chronic systemic disease,
• rupture fetal membranes,
• epidural analgesia.

Trial design

240 participants in 2 patient groups

Pethidine group / study group

Description:

Study group; patients given pethidine; The partogram was recorded during delivery. Cervical examination was performed at 2 hour intervals. Recorded in the file. 4 cm and greater cervical dilatation; 50 mg intramuscular (IM) injection was given to pethidine. 200 Montevideo units uterine contractions were reached. Maternal vital signs, maternal complications and neonatal APGAR scores were recorded by the clinician 0-5-15-30-45-60 minutes after pethidine injection.

Treatment:

Drug: pethidine

control group

Description:

The patients who received placebo injection were included in the control group. Saline was given in placebo.

Treatment:

Drug: Placebo - Concentrate