Ph1 Lobeline Interaction Study - 1

National Institutes of Health (NIH)

Status and phase

Unknown

Phase 1

Conditions

Methamphetamine Dependence

Treatments

Drug: Lobeline

Study type

Interventional

Funder types

NIH

Identifiers

NCT00439504

NIDA-CPU-0012-1

Details and patient eligibility

About

The purpose of this study is to determine if there are significant cardiovascular or other interactions between sublingual lobeline and intravenous methamphetamine.

Sex

Female

Ages

18 to 45 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Be between the ages of 18 and 45 years of age
Be in general good health with a history of methamphetamine (MA) abuse (but not dependence)
If female and of child bearing potential, agrees to use birth control
Be able to understand and provide written informed consent
Have a body mass index between 18 and 30
Have reported use of (MA) during the past three months without experiencing adverse consequence plus a life time MA or amphetamine use history of at least four occasions of use
Have a negative drug test (barbiturates, benzodiazepines, amphetamines, opiates, cocaine, cannabinoids, ethanol) at screening and at the time of admission

Exclusion criteria