Pharmacogenetic and Antidepressant Treatment in Elderly

Centre Hospitalier Universitaire de Besancon

Status: Terminated

Conditions: Depression

Treatments: Biological: urine analysis

Study type: Interventional

Funder types: Other

Identifiers

NCT02856477

R/2007/32

Details and patient eligibility

About

The study aims to assess the therapeutic benefits of the adaptation of the antidepressant dose to the metabolic capacity (cytochrome P450 2D6) of elderly depressed patients.

Therapeutic benefits are evaluated through the enhancement of efficiency, decrease of the action time and the after effects.

Enrollment: 28 patients

Sex: All

Ages: 70+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• current major depressive disorder
• antidepressant treatment

Exclusion criteria

• dextromethorphan contra-indication
• other psychiatric disorder
• kidney failure
• liver failure mini mental State Examination (MMSE)<18

Trial design

28 participants in 2 patient groups

adapted treatment

Experimental group

Description:

the treatment dose is adapted to the metabolic capacity of the patient. intervention: urine analysis

Treatment:

Biological: urine analysis

non-adaptated treatment

Experimental group

Description:

the treatment dose is adapted to the metabolic capacity of the patient. intervention: urine analysis

Treatment:

Biological: urine analysis