Pharmacogenetic of Salbutamol in Pediatric Asthma Crisis (Pegase)

Hôpital Necker-Enfants Malades

Status: Completed

Conditions: Asthma

Study type: Observational

Funder types: Other

Identifiers

NCT02195258

URC Paris centre

Details and patient eligibility

About

this study is designed to identify the genetic factors which can be implicated in the salbutamol responsiveness for asthmatic children in pediatric emergency department

Full description

Patients from 6 to 16 years old consulting for an acute asthma exacerbation and receiving a treatment by salbutamol according to the usual care could be recruited.Saliva from patient were collected using Oragen®.DNA OG-500 kit or swabs.Based on literature review, four SNP were chosen:ADBR2 gene), ARG gene, and GSNOR gene.

Enrollment: 95 patients

Sex: All

Ages: 6 to 16 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• children
• 6-16 years old
• asthmatic patients
• consulting for an exacerbation in a pediatric emergency department
• parental informed consent

Exclusion criteria

• comorbidity
• peak flow no available
• pneumonia

Trial design

95 participants in 1 patient group

salbutamol