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Pharmacogenetic of Salbutamol in Pediatric Asthma Crisis (Pegase)

H

Hôpital Necker-Enfants Malades

Status

Completed

Conditions

Asthma

Study type

Observational

Funder types

Other

Identifiers

NCT02195258
URC Paris centre

Details and patient eligibility

About

this study is designed to identify the genetic factors which can be implicated in the salbutamol responsiveness for asthmatic children in pediatric emergency department

Full description

Patients from 6 to 16 years old consulting for an acute asthma exacerbation and receiving a treatment by salbutamol according to the usual care could be recruited.Saliva from patient were collected using Oragen®.DNA OG-500 kit or swabs.Based on literature review, four SNP were chosen:ADBR2 gene), ARG gene, and GSNOR gene.

Enrollment

95 patients

Sex

All

Ages

6 to 16 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • children
  • 6-16 years old
  • asthmatic patients
  • consulting for an exacerbation in a pediatric emergency department
  • parental informed consent

Exclusion criteria

  • comorbidity
  • peak flow no available
  • pneumonia

Trial design

95 participants in 1 patient group

salbutamol

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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