Pharmacogenetics for Pain Management in Joint Replacement Patients (PGx)

Anderson Orthopaedic Research Institute

Status and phase: Unknown; Phase 3

Conditions: Arthroplasty Complications

Treatments: Diagnostic Test: Pharmacogenomics Testing

Study type: Interventional

Funder types: Other

Identifiers

NCT03772535

AORI 2018-0100

Details and patient eligibility

About

The purpose of this study is to determine the ability to use pharmacogenetic testing in a joint replacement practice to prescribe the most effective pain medicine for a specific patient.

Enrollment: 50 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Primary total hip or total knee arthroplasty cases

Exclusion criteria

• History of narcotic dependence

Trial design

Primary purpose: Screening

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Single Blind

---

50 participants in 2 patient groups

Control Group

No Intervention group

Description:

Subjects in this arm will receive the standard postoperative pain prescription protocol.

Pharmacogenomics Guided Group

Active Comparator group

Description:

Subjects in this group will receive postoperative pain prescriptions based on the results of pharmacogenomic testing.

Treatment:

Diagnostic Test: Pharmacogenomics Testing