Pharmacogenetics of Propofol and Depth of Anesthesia

U

University Hospital, Linkoeping

Status

Completed

Conditions

Propofol
Anesthesia

Study type

Observational

Funder types

Other

Identifiers

NCT01029379
Progen1

Details and patient eligibility

About

Propofol, (2,6-diisopropylphenol) is a short-acting anesthetic drug used for induction and maintenance of anesthesia. The aim of this study is to evaluate plasma concentrations of propofol in relation to depth of anesthesia, measured by continuous EEG and to correlate plasma concentrations with genetic analyses of liver enzymes responsible for drug elimination. Our hypothesis is that there is an individual requirement of Propofol plasma concentration depending on genetic differences in drug elimination. 200 patients, ASA classification 1, planned for elective surgery of a duration of at least 30 minutes will be included in this study.

Enrollment

100 patients

Sex

All

Ages

18 to 50 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • Healthy caucasian patents,
  • (ASAclassification 1) planned for elective surgery,
  • with body mass index 20-30,
  • free from analgetic drug > 12 hours prior to anesthesia

Exclusion criteria

  • Pregnancy,
  • Smoking,
  • allergy to propofol or peanuts,
  • alcohol abuse,
  • non-caucasian

Trial design

100 participants in 1 patient group

200 patients,ASA 1

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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