Pharmacokinetic Analysis of Posaconazole in Lung Transplant Recipients

University of Pittsburgh

Status: Completed

Conditions: Fungal Infection; Lung Transplant Infection

Treatments: Other: collection of blood samples for PK testing

Study type: Interventional

Funder types: Other; Industry

Identifiers

NCT01419678

PRO10110232

Details and patient eligibility

About

This is a single center, observational study of posaconazole PK sampling in lung transplant recipients. The patients enrolled will have up to 6 (3ml) pk samples (a total of 18 ml) and one 10ml blood sample for a total collection of 28ml of blood obtained over the entire study. In addition, the investigators will collect medical record information and any excess BAL samples available during the study (tests done as part of the patient's clinical care and the samples would have been discarded once diagnosis was made).

Full description

PK blood samples will be obtained around a clinical dosing of posaconazole

Enrollment: 20 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• 18 years of age and older receiving posaconazole post transplant as part of their care received a lung transplant

Exclusion criteria

• must meet inclusion criteria

Trial design

Primary purpose: Diagnostic

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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20 participants in 1 patient group

'collection of blood samples for PK testing'

Experimental group

Description:

collection of PK samples around a dosing of Posaconazole

Treatment:

Other: collection of blood samples for PK testing