Pharmacokinetic Drug-Drug Interaction Study

Drugs for Neglected Diseases

Status and phase

Completed

Phase 1

Conditions

Chagas Disease

Treatments

Drug: Benznidazole

Drug: E1224

Study type

Interventional

Funder types

Other

Industry

Identifiers

NCT03892213

DNDi-CH-E1224-002

Details and patient eligibility

About

The purpose of this study is to determine whether benznidazole and E1224 should be administered concomitantly in patients with Chagas Disease as not enough data are available. This study aims to assess cross interactions of these two compounds.

Full description

Benznidazole and E1224 are intended to be administered concomitantly in patients with Chagas disease. Thus, an in vivo interaction study in healthy volunteers may be justified as the two drugs are intended to be administered concomitantly in patients and no in vivo nor in vitro data are available.

In addition both interactions (potential for benznidazole to interact on the pharmacokinetic (PK) of E1224 and potential for E1224 on the PK of benznidazole should be studied.

Benznidazole t1/2 is quite short (12 h) whereas E1224 t1/2 is very long (more than 200 h). Therefore it was chosen to study the interaction of E1224 at steady-state while interaction of benznidazole after single dose appears more appropriate instead of a classical randomized cross-over design.

Enrollment

28 patients

Sex

Male

Ages

18 to 45 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Male healthy volunteers 18 to 45 years of age;
Light smokers (less than 5 cigarettes per day) or subjects who are non-smokers;
Male subjects with a body weight of at least 50 kg and a body mass index (BMI) calculated as weight in kg/height (in m2) from 18 to 28 kg/m2 at screening;
Able to communicate well with the Investigator and research staff and to comply with the requirements of the entire study;
Provision of written informed consent to participate as shown by a signature on the volunteer consent form;

Exclusion criteria

Who on direct questioning and physical examination have evidence of any clinically significant acute or chronic disease, including known or suspected HIV, hepatites B virus (HBV) or hepatites C virus (HCV) infection;
Who has positive diagnosis of T. cruzi infection indicated by Conventional serology;
With any clinically significant abnormality following review of pre-study laboratory tests, vital signs, full physical examination and 12-lead ECG;
Who forfeit their freedom by administrative or legal award or who were under guardianship;
Unwilling to give their informed consent;
Who have a positive laboratory test for Hepatitis B surface antigen (HbsAg), or anti-HIV 1/2 or anti- HCV antibodies;
Who have a history of allergy (serious or not), allergic skin rash, asthma, intolerance, sensitivity or photosensitivity to any drug;
Who are known or suspected alcohol or drug abusers (more than 14 units of alcohol per week, one unit = 8 g or about 10 mL of pure alcohol);