Pharmacokinetic Interaction Between HGP0904, HGP0608 and HGP1405

Hanmi Pharmaceutical

Status and phase: Completed; Phase 1

Conditions: Hypertension(HTN)

Treatments: Drug: HGP1405; Drug: HGP0608; Drug: HGP0904

Study type: Interventional

Funder types: Other; Industry

Identifiers

NCT02387554

HM-ALCH-101

Details and patient eligibility

About

The purpose of this study is to investigate the pharmacokinetic interaction and safety between HGP0904, HGP0608 and HGP1405 when administered alone and in combination in healthy male volunteers

Enrollment: 33 patients

Sex: Male

Ages: 19 to 45 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• 19~45 years old
• Healthy men

Exclusion criteria

• Gastroentestinal disease affecting drug absorption

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: None (Open label)

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33 participants in 4 patient groups

HGP0904+HGP0608+HGP1405

Experimental group

Description:

amlodipine + losartan + chlorthalidone

Treatment:

Drug: HGP0904

Drug: HGP0608

Drug: HGP1405

HGP0904

Active Comparator group

Description:

amlodipine

Treatment:

Drug: HGP0904

HGP0608

Active Comparator group

Description:

losartan

Treatment:

Drug: HGP0608

HGP1405

Active Comparator group

Description:

chlorthalidone

Treatment:

Drug: HGP1405