Pharmacokinetic of Sevoflurane During a 48h Sedation in Intensive Care Unit With AnaConDa® (Anaconda)

University Hospital, Clermont-Ferrand

Status: Completed

Conditions: Sedation

Treatments: Other: sevoflurane

Study type: Interventional

Funder types: Other

Identifiers

NCT01196754

CHU-0079

Details and patient eligibility

About

This is a prospective clinical monocentric study in ICU with sedated ventilated patients with sevoflurane during 48 h with the AnaConda® system, establishing pharmacokinetic model of sevoflurane.

Full description

Prospective clinical monocentric study in ICU with sedated ventilated patients with sevoflurane during 48 h with the AnaConda® system, establishing pharmacokinetic model of sévoflurane and its metabolites (hydroxyfluroisopropanol, fluoride)

Enrollment: 12 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Adult patients ventilated more than 48 h
• Stable respiratory and hemodynamic conditions
• Consent of patients or family
• Arterial line

Exclusion criteria

• Acute kidney injury
• Obesity
• Sevoflurane anaphylaxia

Trial design

12 participants in 1 patient group

sevoflurane

Other group

Treatment:

Other: sevoflurane