Pharmacokinetics and Pharmacdynamics of Sildenafil
Status
Conditions
Treatments
Details and patient eligibility
About
The study is being done to investigate what happens to sildenafil in the body and how long it takes to get rid of this drug. Understanding how long the drug stays in the body and how it is changed by the body will help doctors determine the best dose. We also want to learn how well the medicine works based on the size of the dose or amount in the bloodstream.
Full description
There is no data regarding sildenafil drug disposition in infants and children with pulmonary hypertension. Sildenafil is used at The Children's Hospital of Philadelphia for the treatment of pulmonary hypertension. Patients receiving sildenafil as standard of care will be approached for consent.
Enrollment
Sex
Ages
Volunteers
Inclusion criteria
- Receive enteral sildenafil as standard of care
- > 28 days to >18 years of age
- Informed consent/assent
Exclusion criteria
- Parents/guardians and/or subjects who, in the opinion of the investigator, may be noncompliant with study schedules or procedures.
Trial design
9 participants in 1 patient group
Trial contacts and locations
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Data sourced from clinicaltrials.gov
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