Pharmacokinetics and Pharmacodynamics of Nasally Applied Esketamine

University Hospital Basel

Status and phase: Completed; Phase 1

Conditions: Pain

Treatments: Drug: esketamine hydrochloride

Study type: Interventional

Funder types: Other

Identifiers

NCT00847418

EKBB 351/08, 2009DR1015

Details and patient eligibility

About

The purpose of this study is the determination of blood concentration and the effectiveness of esketamine after nasal application.

Sex: Male

Ages: 18 to 45 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• male
• age ≥18 years ≤ 45 years
• healthy
• non-smoking
• BMI 18-27

Exclusion criteria

• abuse of drugs
• known or supposed hypersensitivity and/or contraindication against ketamine or additives
• participation of another clinical study within the last 30 days
• chronic obstructed nose breathing or nasal polyps
• dug allergy
• blood donation within the last two months

Trial design

0 participants in 1 patient group

Esketamine

Experimental group

Treatment:

Drug: esketamine hydrochloride