Pharmacokinetics and Safety of Sancuso and IV Granisetron in Pediatrics Aged 6 to 12 Years

Kyowa Kirin

Status and phase

Withdrawn

Phase 1

Conditions

Chemotherapy Induced Nausea and Vomiting

Treatments

Drug: IV granisetron

Drug: Sancuso

Study type

Interventional

Funder types

Industry

Identifiers

NCT01596413

392MD/46/C

Details and patient eligibility

About

The purpose of this study is to determine the dosing strategy for adolescents aged 6 to 12 years.

Full description

This is an open-label, multi-center, cross-over study in male and female pediatric cancer patients, aged 6 to 12 years of age who are receiving at least 2 cycles of emetogenic chemotherapy requiring 5-HT3 antagonist treatment of up to 5 days duration. The study is designed to evaluate the safety and PK of transdermal granisetron (Sancuso® patch) in a pediatric population (aged 6 to 12 years), using a population PK approach.

Sex

All

Ages

6 to 12 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

6 to 12 years of age inclusive at screening.
Written patient or parental (or appropriate legal representative) IRB approved informed consent as appropriate.
Written patient assent (as appropriate).
Confirmed malignancy.
Scheduled to receive 2 or more cycles* of emetogenic chemotherapy requiring 5-HT3 antagonist treatment.
Scheduled to receive one or more consecutive days of 5-HT3 antagonist treatment, per cycle, as CINV prophylaxis.
- The cycles of chemotherapy must be consecutive (i.e. one followed by the other) but do not have to be the first and second cycle of a line of treatment.

Exclusion criteria

Hypersensitivities, allergies or contraindications to study medications; intolerance of medical tape or sticking plaster.
Clinical or laboratory signs and symptoms of significant cerebral, cardiovascular, respiratory, renal, hepatobiliary, pancreatic or infectious disease, which in the Investigator's judgment may interfere with the study assessment or completion of the study.
Patients with a known history or predisposition to cardiac conduction interval abnormalities, including QT Syndrome, or known family history of long QT Syndrome or taking medications that are known to prolong the QT interval.
Patients scheduled to have routine surgery during the study duration.
Patients with a life expectancy of < 6 months.
Scarring or significant skin disease on both upper arms.
Female patients who are pregnant or breast-feeding. All post menarche female patients must have a pregnancy test at screening.
Patients who are known or thought to be sexually active must use effective birth control.**
Administration of other investigational drugs within 30 days preceding the screening visit, except for anticancer treatments.
Any conditions associated with non-compliance.
- Effective birth control includes absolute abstinence or double barrier birth control methods i.e. condom and one of the following: combined oral contraceptive, diaphragm, depot contraceptive injection.