Pharmacokinetics Ertapenem Burns

Nantes University Hospital (NUH)

Status and phase: Completed; Phase 4

Conditions: Burn Patients

Treatments: Drug: Ertapenem

Study type: Interventional

Funder types: Other

Identifiers

NCT01497990

09/3-W

Details and patient eligibility

About

This study will examine the pharmacokinetics of ertapenem in ventilated badly (> 30% SCT) burn patients.

Enrollment: 8 patients

Sex: All

Ages: 18 to 70 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients aged 18 to 70 years
• Burned on 30 to 60% of their body surface
• Mechanical ventilation
• Hospitalized in the intensive care unit of Nantes University Hospital for less than 8 days.
• Which the family gave consent
• insured

Exclusion criteria

• Patients whose family refused to sign the consent for participation.
• Patients allergic to beta lactam
• Patients with renal failure with creatinine clearance <80 ml.mn-1
• Pregnant women
• Persons protected by the law

Trial design

Primary purpose: Treatment

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

---

8 participants in 1 patient group

Ertapenem

Experimental group

Description:

The patient received two injections of ertapenem, at a dose of 1g.j-1 by intravenous injection of 30 minutes, separated by 24 h.

Treatment:

Drug: Ertapenem