Pharmacokinetics of Antibiotics During Extracorporeal Membrane Oxygenation (ECMO) Support

Boston Children's Hospital

Status: Terminated

Conditions: Drug Effect

Treatments: Drug: Cefazolin; Drug: piperacillin-tazobactam

Study type: Observational

Funder types: Other

Identifiers

NCT03922451

IRB-P00030970

Details and patient eligibility

About

This study will measure plasma concentrations of piperacillin-tazobactam and cefazolin in pediatric patients supported with extracorporeal membrane oxygenation (ECMO) aiming to better understand the pharmacokinetics of these medications in this in vivo setting.

Enrollment: 4 patients

Sex: All

Ages: Under 18 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• supported on ECMO
• receive piperacillin-tazobactam or cefazolin as part of routine care or infection management

Exclusion criteria

• >= 18 years
• No Consent provided

Trial design

4 participants in 1 patient group

Pediatric patients supported on ECMO

Treatment:

Drug: piperacillin-tazobactam

Drug: Cefazolin