Pharmacokinetics of Antiepileptics in Patients on CRRT (PADRE)

University of Maryland Baltimore (UMB)

Status and phase: Completed; Phase 4

Conditions: Renal Failure; Acute Kidney Injury; Renal Insufficiency; Pharmacokinetics

Treatments: Drug: Phenytoin; Drug: Ketamine; Drug: Lacosamide; Drug: Phenobarbital; Drug: Valproic Acid; Drug: Levetiracetam

Study type: Observational

Funder types: Other

Identifiers

NCT03632915

HP-00066222

Details and patient eligibility

About

The purpose of the study is to measure levels of any of the following AEDs (levetiracetam, phenobarbital, phenytoin, ketamine, valproic acid, lacosamide) in blood and effluent on critically ill patients receiving CRRT in order to characterize drug pharmacokinetics and optimize dosing strategies in patients on CRRT.

Enrollment: 18 patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Expected to be on CRRT and receive any of the following for more than 24 hrs
• Expected to survive for more than 24 hrs
• Achievement of steady state drug concentrations prior to study enrollment

Exclusion criteria

• Pregnancy
• Age < 18
• Prisoner

Trial design

18 participants in 1 patient group

No study intervention

Description:

No study intervention

Treatment:

Drug: Levetiracetam

Drug: Ketamine

Drug: Lacosamide

Drug: Phenobarbital

Drug: Valproic Acid

Drug: Phenytoin