Pharmacokinetics of Curcumin in Healthy Volunteers

Mass General Brigham

Status: Completed

Conditions: Healthy

Treatments: Drug: Curcumin

Study type: Interventional

Funder types: Other

Identifiers

NCT00181662

2005P-000650

P50CA105009-01 (U.S. NIH Grant/Contract)

Details and patient eligibility

About

This study looks to describe the pharmacokinetics of curcumin delivered as a single oral dose in healthy female volunteers. The impact of piperine and silybin on the pharmacokinetics of curcumin is also studied.

Full description

Healthy volunteers are seen on three separate visits and receive 4 gm of curcumin as a single oral dose either alone or with piperine or with silybin. Serial timed blood draws then are collected for pharmacokinetic analysis.

Sex: Female

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Healthy volunteer
• On no medications except for birth control pills
• Signed informed consent

Exclusion criteria

• Pregnant
• Comorbid disease

Trial design

Primary purpose: Treatment

Allocation: Non-Randomized

Interventional model: Crossover Assignment

Masking: None (Open label)