Pharmacokinetics of Epinephrine During Cardiac Arrest

Haukeland University Hospital

Status: Completed

Conditions: Cardiac Arrest

Treatments: Drug: Epinephrine

Study type: Observational

Funder types: Other

Identifiers

NCT03036202

1471-74

Details and patient eligibility

About

To determine the pharmacokinetics of epinephrine during cardiac arrest.

Full description

The aim of out study is to determine the pharmacokinetics in humans during cardiac arrest, following a single dose of epinephrine. Venous samples will be withdrawn every minute the first five minutes following a single dose.

The aim of the study is to determine T1/2 in a clinical setting and to determine time to peak concentration.

Enrollment: 8 patients

Sex: All

Ages: 18 to 85 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age 18-85 yrs
• Witnessed non-traumatic cardiac arrest.
• Probable cardiac origin
• Treated by Bergen Emergency Medical Services

Exclusion criteria

• Terminal illness
• Residents of nursery homes
• Obvious dead
• Hypothermic patients
• Epinephrine administered before arrival of study physician

Trial design

8 participants in 1 patient group

one group

Description:

All patients treated for cardiac arrest, meeting our inclusions criteria will be enrolled in the study. No interventions regarding the national guidelines will be jeopardized, as the plasma concentration following a single dose of epinephrine will be measured in all patient.

Treatment:

Drug: Epinephrine