Pharmacokinetics of Ertapenem in Continuous Venovenous Hemodialysis
Status and phase
Conditions
Treatments
Details and patient eligibility
About
Critically ill patients in the intensive care unit often receive continuous hemodialysis to treat their kidney failure. Ertapenem is an antibiotic often used in these patients. Continuous dialysis may remove ertapenem, putting patients at risk for inappropriate treatment of their infection. This study will determine how much ertapenem is removed by continuous hemodialysis.
Full description
Subjects receiving CVVHD will receive a one gram dose of ertapenem. Serial blood samples over 24 hours will be taken to assess the ertapenem blood concentrations over time. Spent dialysate and urine samples (if any) will also be measured for ertapenem content to determine how much drug is removed by CVVHD and kidneys. A pharmacokinetic evaluation will be made to determine what is the most appropriate dose for this drug in patients receiving CVVHD to achieve pharmacokinetic and pharmacodynamic goals.
Enrollment
Sex
Ages
Volunteers
Inclusion criteria
- Hospitalized in ICU
- Receiving Continuous hemodialysis
- Prescribed ertapenem
- Informed consent granted
Exclusion criteria
- < 18 years of age
- Allergy to ertapenem or other carbapenem antibiotic
- Severe, life-threatening reaction to penicillin or cephalosporins
- Patients experiencing or with history of CNS disorders (eg: seizure, stroke)
- Patients experiencing CNS infection
- Inability to complete 24 hours of CVVHD
- Concurrent use of other extracorporeal therapies such as extracorporeal membrane oxygenation, plasmapheresis or intermittent hemodialysis
- Inability to obtain informed consent
- Pregnant and/or breastfeeding women
Trial design
8 participants in 1 patient group
Trial contacts and locations
Loading...
Data sourced from clinicaltrials.gov
Clinical trials
Research sites
Resources
Legal