Pharmacokinetics of Micafungin in Critically Ill Patients

University Medical Center Groningen (UMCG)

Status: Completed

Conditions: Critical Illness; Invasive Candidiasis

Study type: Observational

Funder types: Other

Identifiers

NCT01716988

NL39246.042.12

Details and patient eligibility

About

A study of micafungin in ICU versus non-ICU patients showed a significantly lower treatment success in ICU patients compared with non-ICU patients. It is known that in critically ill patients, alterations in function of various organs and body systems can influence the pharmacokinetics and hence the plasma concentration of a drug. The pharmacokinetic parameters of micafungin in critically ill patients are most likely different, but this has not been specifically studied.

The pharmacokinetic parameters of micafungin in critically ill patients will be established and plasma concentrations of micafungin will be correlated with disease severity.

Enrollment: 19 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Treatment with micafungin.
• Admission to an ICU.
• Age ≥ 18 years.
• Invasive candidiasis.

Exclusion criteria

• Blood sampling not possible.

Trial design

19 participants in 1 patient group

Micafungin