Pharmacokinetics of Oxytocin at Cesarean Delivery (Peacocks)

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The Washington University

Status

Completed

Conditions

Postpartum Hemorrhage

Treatments

Device: Shore durometer
Drug: oxytocin

Study type

Observational

Funder types

Other

Identifiers

NCT03898882
201810134

Details and patient eligibility

About

The primary objective is to obtain data to inform the design of a population pharmacokinetic study of oxytocin after administration at CD as per standard institutional practice.

Full description

In this pilot study the investigators will compare plasma oxytocin concentrations measured in arterial and venous blood, after oxytocin administration at cesarean delivery, in order to assess the validity of venous samples. They will also measure oxytocinase to explore how levels vary around the time of delivery of the placenta and to assess the effect that this may have on the metabolism of oxytocin.

Enrollment

30 patients

Sex

Female

Ages

18 to 45 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

  • Term singleton pregnancy
  • Age 18-45 years of age
  • ASA classification 2 or 3
  • Scheduled cesarean delivery under neuraxial anaesthesia

Exclusion criteria

  • Age or ASA classification outside of inclusion criteria
  • Need for general anaesthesia
  • Absence of consent
  • Inability to communicate in English or other barrier to providing informed consent

Trial design

30 participants in 2 patient groups

BMI 20 - 29.9 kg/m2
Treatment:
Drug: oxytocin
Device: Shore durometer
BMI > 30 kg/m2
Treatment:
Drug: oxytocin
Device: Shore durometer

Trial contacts and locations

0

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Data sourced from clinicaltrials.gov

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