Pharmacokinetics of Oxytocin at Cesarean Delivery (Peacocks)
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Details and patient eligibility
About
The primary objective is to obtain data to inform the design of a population pharmacokinetic study of oxytocin after administration at CD as per standard institutional practice.
Full description
In this pilot study the investigators will compare plasma oxytocin concentrations measured in arterial and venous blood, after oxytocin administration at cesarean delivery, in order to assess the validity of venous samples. They will also measure oxytocinase to explore how levels vary around the time of delivery of the placenta and to assess the effect that this may have on the metabolism of oxytocin.
Enrollment
Sex
Ages
Volunteers
Inclusion criteria
- Term singleton pregnancy
- Age 18-45 years of age
- ASA classification 2 or 3
- Scheduled cesarean delivery under neuraxial anaesthesia
Exclusion criteria
- Age or ASA classification outside of inclusion criteria
- Need for general anaesthesia
- Absence of consent
- Inability to communicate in English or other barrier to providing informed consent
Trial design
30 participants in 2 patient groups
Trial contacts and locations
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Data sourced from clinicaltrials.gov
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