Pharmacokinetics of Sedatives and Analgesics During Extracorporeal Membrane Oxygenation (ECMO) Support

Boston Children's Hospital

Status: Enrolling

Conditions: Drug Effect

Treatments: Drug: Morphine; Drug: Dexmedetomidine; Drug: Fentanyl; Drug: Midazolam

Study type: Observational

Funder types: Other

Identifiers

NCT03593408

IRB-P00028380

Details and patient eligibility

About

This study will measure plasma concentrations of dexmedetomidine, fentanyl, morphine and midazolam in pediatric patients supported with extracorporeal membrane oxygenation (ECMO) aiming to understand the pharmacokinetics of these drugs in this setting.

Enrollment: 20 estimated patients

Sex: All

Ages: Under 17 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• supported on ECMO
• receiving one or a combination of the following drugs dexmedetomidine, fentanyl, midazolam or morphine as part of sedation management

Exclusion criteria

-none

Trial design

20 participants in 1 patient group

Pediatric Patients on ECMO Support

Treatment:

Drug: Midazolam

Drug: Fentanyl

Drug: Dexmedetomidine

Drug: Morphine