Pharmacological Recruitment of Endogenous Neural Precursors to Promote Pediatric White Matter Repair: Establishing Correlations Between Visual Outcomes, Saccadic Function and MEG Oscillations in Children With Demyelinating Disorders in Comparison to Healthy Control Children

The Hospital for Sick Children

Status: Completed

Conditions: Demyelinating Disease

Study type: Observational

Funder types: Other

Identifiers

NCT03010826

1000053920

Details and patient eligibility

About

The neural circuits in our brains require a layer of insulation in order to transmit signals in a rapid and efficient fashion. This insulation is called White Matter and is comprised of a specific type of brain cell called an oligodendrocytes. Damage to brain white matter occurs following injury and in disorders like Multiple Sclerosis and results in sensory, motor, and cognitive problems. Currently there are no effective medical therapies to promote brain repair and reduce disability following damage to white matter. In this project, we hope to change the situation by encouraging the brain itself to generate new oligodendrocytes and thus new white matter. Our first step is to find measures sensitive to white matter growth.

Enrollment: 78 patients

Sex: All

Ages: 5 to 18 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Experienced a demyelinating event (Only applicable to patient subjects)
• Between the ages of 5 years to 18 years and 11 months of age
• Has either English as his or her native language or has had at least two years of schooling in English

Exclusion criteria

• Children with non-demyelinating etiologies of white matter dysfunction (i.e., metabolic disorders, vasculitis, and non-specific MRI abnormalities
• Is younger than 5 years of age
• Is 18 years and 11 of age or older
• Has a prior history of traumatic brain injury, neurological disorder, cerebral palsy, developmental delay, or learning disability
• Requires sedation for brain scanning
• Is claustrophobic, as brain scanning requires children to enter a tunnel in the MRI machine

Trial design

78 participants in 2 patient groups

40 Demyelinating Disease patients

40 Non-patient participants