Phase 1 Study Accessing the Safety and Tolerability of CBP-307

Connect Biopharma

Status and phase

Completed

Phase 1

Conditions

Autoimmune Diseases

Treatments

Drug: CBP-307

Drug: Placebo

Study type

Interventional

Funder types

Other

Industry

Identifiers

NCT02280434

CBP-307AU001

Details and patient eligibility

About

This study will evaluate the safety, tolerability, pharmacokinetics and pharmacodynamics of CBP-307 following oral single and multiple escalating dose administration in healthy subjects.

Full description

This study will evaluate the safety, tolerability, pharmacokinetics and pharmacodynamics of CBP-307 following oral single and multiple escalating dose administration in healthy subjects. The study will have two parts: Part 1 will assess 5 dose levels of the drug in single dosing; and Part 2 will evaluate 3 dose levels in 28-day repeat dosing. The effect of food will also be evaluated in a single dosing study.

Enrollment

64 estimated patients

Sex

Male

Ages

18 to 55 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Informed consent must be obtained in writing for all subjects at enrollment into the study
Healthy male subjects age between 18 and 55 years, inclusive
Body mass index (BMI) between 19 and 30 kg/m2, inclusive
No clinically significant findings in the medical history and physical examination, especially with regard to the liver and gastrointestinal systems
No clinically significant laboratory values and urinalysis, unless the investigator considers any abnormality to be clinically irrelevant
Normal ECG, blood pressure, and heart rate, unless the investigator considers any abnormality to be clinically irrelevant
Resting heart rate ≥ 55 bpm

Exclusion criteria

Family history of premature CHD (Coronary Heart Disease)
Any condition requiring the regular use of any medication
Exposure to prescription medications or to drugs known to interfere with metabolism of drugs within 30 days prior to screening
Exposure to any other medication, including over-the counter medications, herbal remedies and vitamins 14 days prior to randomization (except paracetamol (see Section 5.2 Prior and concomitant treatments)
Participation in another study with any investigational drug in the 2 months preceding the study
Treatment in the previous 3 months with any drug known to have a well defined potential for toxicity to a major organ
Positive urine cotinine result at screening
Be in the exclusion period of any previous study with investigational drugs
Symptoms of a clinically significant illness in the 3 months before the study
Presence or sequelae of gastrointestinal, liver or kidney disease, or other conditions known to interfere with the absorption, distribution, metabolism, or excretion of drugs
Chronic constipation or diarrhea, irritable bowel syndrome, inflammatory bowel disease
Hemorrhoids or anal diseases with regular or recent presence of blood in feces
History of significant allergic disease (e.g. medications) and acute phase of allergic rhinitis in the previous 2 weeks before randomization or any food allergy
Blood or plasma donation of more than 500 ml during the previous 2 month before randomization and/or more than 50 ml in the 2 weeks prior to screening
Subjects at risk for tuberculosis (TB), specifically subjects with: Current clinical, radiographic or laboratory evidence of active TB; history of active TB unless there is documentation that the prior anti-TB treatment was appropriate in duration and type;latent TB which has not been successfully treated; a positive quantiFERON® test at screening or within 6 months prior to Day 1
Known positive test for HIV
Known positive test for hepatitis B (antigens HBs, antibody HBc) or C, unless caused by immunization
History of shingles or recurrent episodes of HSV1 or HSV2 infections
Current evidence of drug abuse or history of drug abuse within one year before randomization
History of alcohol abuse or active alcoholism as defined in Appendix A Definition of alcohol abuse
Mental condition rendering the subject incapable to understand the nature, scope, and possible consequences of the study
Adults under guardianship and people with restriction of freedom by administrative or legal decisions
Unlikely to comply with the clinical study protocol; e.g. uncooperative attitude, inability to return for follow-up visits, and improbability of completing the study
Subject is the investigator or any sub-investigator, research assistant, pharmacist, study coordinator, other staff or relative thereof directly involved in the conduct of the protocol.
Systolic blood pressure less than 95 mmHg or greater than 140 mmHg, or diastolic blood pressure less than or equal to 50 mmHg or greater than or equal to 95 mmHg.
Subjects with resting heart rate less than 55 beats per minute or greater than 90 beats per minute.