Phase I / II Study of Enadenotucirev by Sub-acute Fractionated IV Dosing in Cancer Patients (EVOLVE)

Akamis Bio

Status and phase

Completed

Phase 2

Phase 1

Conditions

Solid Tumours of Epithelial Origin

Metastatic Bladder Cancer

Metastatic Colorectal Cancer

Treatments

Biological: Enadenotucirev

Study type

Interventional

Funder types

Industry

Identifiers

NCT02028442

ColoAd1-1001

Details and patient eligibility

About

This is a multicentre, open-label, Phase I/II study of enadenotucirev in patients with either solid tumour of epithelial origin not responding to standard therapy or for whom no standard treatment exists (Phase I dose escalation stage Single cycle), mCRC not responding to standard therapy (Phase I dose escalation Repeat cycle cohort expansion stage ), mCRC not responding to standard therapy or advanced or metastatic bladder cancer not candidate for chemotherapy (Phase Ib) or mCRC in stable disease or partial response after 3-4 months of first line standard of care chemotherapy (Phase II).

Enrollment

61 patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria:

Patients must provide written informed consent
Age ≥ 18 years and the patient must be at least the legal age limit to be able to give consent within the jurisdiction the study is taking place.
ECOG performance status 0 or 1
Predicted life expectancy of 3 months or more
Ability to comply with study procedures in the Investigator's opinion
Recovered to Grade 1 from the effects (excluding alopecia) of any prior therapy for their malignancies
Adequate renal function
- Creatinine ≤ 1.5 mg/dL or calculated creatinine clearance using the Cockcroft-Gault formula ≥ 60 mL/min, or measured creatinine clearance ≥ 60 mL/min, Haematuria: dipstick ≤ 2+
- Proteinuria: dipstick ≤ 2+
Adequate hepatic function
- Serum bilirubin < 1.5 mg/dL
- Aspartate transaminase (AST) and alanine transaminase (ALT) ≤ 3x upper limit of normal (ULN)
Adequate bone marrow function:
- Absolute neutrophil count (ANC) ≥ 1.5 x 109/L
- Platelets ≥ 100 x 109/L
- Haemoglobin ≥ 100 g/L for UCC and ≥ 90 g/L for other cancers
Adequate coagulation tests: international normalised ratio (INR) ≤ 1.5 x ULN
For females of childbearing potential (defined as <2 years after last menstruation or not surgically sterile), a negative serum pregnancy test must be documented within 14 days prior to first administration of study treatment
For women who are not postmenopausal (24 months of amenorrhea) or surgically sterile (absence of ovaries and/or uterus): agreement to use two adequate methods of contraception, during the treatment period and for at least 3 months after the last dose of study drug
For men: agreement to use a barrier method of contraception during the treatment period and for at least 6 months after the last dose of study drug
At least 3 weeks since any dose of IV systemic chemotherapy and at least two weeks since any oral dose of capecitabine at the time of first administration of ColoAd1.

Phase I Specific Inclusion Criteria:

Dose Escalation Stage only (except Repeat Cycle Cohort):

Solid tumour of epithelial origin not responding to standard therapy or for whom no standard treatment exists

Dose Expansion Stage Single Cycle and Dose Escalation Stage Repeat Cycle Cohort:

mCRC not responding to standard therapy
≤ 3 prior lines of systemic therapy for advanced disease OR ≤ 4 prior lines of systemic therapy for advanced disease if one of the 4 lines was an anti EGFR therapy given as a single agent or combined to a previously administered chemotherapy regimen Phase Ib:mCRC not responding to standard therapy
no more than 3 prior lines of systemic therapy for advanced disease OR no more than 4 prior lines of systemic therapy for advanced disease if one of the 4 lines was an anti EGFR therapy given as a single agent or combined to a previously administered chemotherapy regimen
Advanced or metastatic UCC, who have received a maximum of one chemotherapy-containing regimen and a maximum of one other systemic treatment with biologic agents only.

Phase II Specific Inclusion Criteria:

mCRC
Have received 3 - 4 months of first line chemotherapy with either FOLFOX, FOLFIRI or CAPOX, with or without bevacizumab
At least one measurable lesion according to RECIST 1.1 criteria
Documented partial response or stable disease
Eligible to receive chemotherapy with FOLFOX or CAPOX after a short chemotherapy interruption (3 to 4 weeks)

Exclusion Criteria for all Patients:

Pregnant or breast feeding females;
Known history or evidence of significant immunodeficiency due to underlying illness (e.g. human immunodeficiency virus [HIV]/acquired immunodeficiency syndrome [AIDS]) and/or medication (e.g. systemic corticosteroids, or other immunosuppressive medications including cyclosporine, azathioprine, interferons, within the past 4 weeks)
Splenectomy
Prior allogeneic or autologous bone marrow or organ transplantation
Active infections requiring antibiotics, physician monitoring, or recurrent fevers >38.0 degrees centigrade associated with a clinical diagnosis of active infection
Active viral disease or known positive serology for HIV, hepatitis B or hepatitis C;
Use of the following anti-viral agents: ribavirin, adefovir, lamivudine or cidofovir within 7 days prior to day 1; or pegylated interferon (PEG-IFN) (within 14 days prior to first administration of ColoAd1)
Administration of an investigational drug within 28 days prior to first dose of ColoAd1
Major surgery within 4 weeks or radiotherapy within 3 weeks prior to first dose of ColoAd1
Another primary malignancy within the past 3 years (except for non melanoma skin cancer or cervical cancer in situ)
Central nervous system (CNS) metastasis that is symptomatic and/or requires treatment
Any condition or illness that, in the opinion of the Investigator or the medical monitor, would compromise patient safety or interfere with the evaluation of the safety of the drug
Known allergy to treatment medication or its excipients
Any other medical or psychological condition that would preclude participation in the study or compromise ability to give informed consent

Phase II Specific Exclusion Criteria:

Progression on first line therapy
A complete response on first line therapy
Use of first line therapy for longer than 4 months
Use of any first line treatment with a chemotherapy regimen other than FOLFOX, FOLFIRI or CAPOX (each with or without bevacizumab)
More than 6 weeks since the last administration of 5 FU, capecitabine, oxaliplatin or irinotecan