Phase I Platinum Based Chemotherapy Plus Indomethacin (PIFA)

UMC Utrecht

Status and phase

Completed

Phase 1

Conditions

Ovarian Neoplasms

Colorectal Neoplasms

Esophageal Neoplasms

Treatments

Drug: Indomethacin

Study type

Interventional

Funder types

Other

Identifiers

NCT01719926

NL40487.041.12

Details and patient eligibility

About

Mesenchymal stem cells (MSCs) are present in the circulation of cancer patients, and are recruited to the stroma of both the primary tumor and metastasis. Recent preclinical research has shown that in response to platinum-based chemotherapy, MSCs secrete two specific platinum-induced fatty acids (PIFAs) which induce resistance to a broad spectrum of chemotherapies. The secreted PIFAs are the fatty acid oxo-heptadecatetraenoic acid (KHT) and the omega-3 fatty acid hexadecatetraenoic acid (16:4). These PIFAs are produced via the COX-1 pathway. COX inhibitors, including indomethacin. This phase 1 study explores the safety of combining indomethacin with platinum containing chemotherapy.

Enrollment

13 patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Subjects with a histological proven malignancy receiving cisplatin combined with gemcitabine or 5FU/capecitabine. (cisplatin dose range 60-80 mg/m2) (Arm I) or CAPOX (oxaliplatin, capecitabine) (Arm II) in a 21 day cycle.
Age ≥ 18 years
Platinum-based chemotherapy naïve for at least 6 months.
Subjects with at least one evaluable lesion.
WHO Performance Status of 0 or 1.
Female participants should be of non-child bearing potential either physiologic or by using adequate contraception, have a negative serum pregnancy test, and refrain from breast feeding.
Written informed consent.

Exclusion criteria

Known or suspected allergy or hypersensitivity to indomethacin or any agent given in association with this trial, in particular subjects who have a history of severe hypersensitivity reactions to anti-emetics (5-HT3 antagonists, metoclopramide or corticosteroids) and acetylsalicylic acid or other prostaglandin synthetase inhibitors.
Symptomatic brain or meningeal tumors
Subjects with seizure disorder requiring medication (such as corticosteroids or anti-epileptics).
Any of the following concurrent severe and/or uncontrolled medical conditions which could compromise participation in the study:
Uncontrolled high blood pressure, history of labile hypertension, or history of poor compliance with an antihypertensive regimen
Unstable angina pectoris
Symptomatic congestive heart failure NYHA class ≥ 3 (see appendix 13.6)
Myocardial infarction ≤ 6 months prior to randomization
Serious uncontrolled cardiac arrhythmia
Active peptic ulcer disease, gastritis, inflammatory bowel disease.
History of active gastrointestinal bleeding
History of cerebrovascular disease
Bleeding diathesis
Chronic renal disease defined as GFR (MDRD) <60 ml/min
Absolute Neutrophil Count (ANC) < 1.5 x 109/L (< 1500/mm3)
Platelets (PLT) < 100 x 109/L (< 100,000/mm3)
Hemoglobin (Hgb) < 6.0 mmol/l (patients may be transfused to achieve adequate Hb)
Partial thromboplastin time (PTT) > 1,5 x ULN
Serum bilirubin > 1.5 ULN
Aspartate aminotransferase (AST/SGOT) and alanine aminotransferase (ALT/SGPT) > 3.0 x ULN (> 5 x ULN if liver metastases present)
Patients who are unable or unwilling to comply with the protocol
Chronic treatment with a corticosteroid agent (nebulized corticosteroids are allowed)
Patients who received radiation therapy within 4 weeks of the start of the study
Patients who received an experimental agent less than 4 weeks before start of the study.
Patients who used Omega-3/omega-6 containing products, including fish oil products less than 2 weeks before start of the study.
Chronic use of NSAID's and/or acetylsalicylic acid and/or other prostaglandin synthetase inhibitors.
Use of anticoagulant therapy