Phase I Study of Colchicine Therapy in Childhood Hepatic Cirrhosis

National Center for Research Resources (NCRR)

Status and phase: Unknown; Phase 1

Conditions: Cirrhosis; Liver Cirrhosis

Treatments: Drug: colchicine

Study type: Interventional

Funder types: Other; NIH

Identifiers

NCT00004368

CHD-1089

199/11947

Details and patient eligibility

About

OBJECTIVES:

I. Investigate the efficacy and safety of colchicine therapy in improving hepatic function and reducing hepatic fibrosis (scarring) in children with hepatic cirrhosis.

Full description

PROTOCOL OUTLINE: Patients receive colchicine orally twice daily for 24 months. After the first month, the dose of colchicine will increase and remain at that dose for the duration of study.

Patients are evaluated every 6 months during study.

Sex: All

Ages: Under 17 years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

• Advanced hepatic fibrosis or cirrhosis in children
• Not pregnant