Phase I Study of Orally Administered Aminolevulinic Acid for Resection of Malignant Astrocytomas

Johns Hopkins Medicine

Status and phase

Terminated

Phase 1

Conditions

Glioma

Astrocytoma

Treatments

Drug: 5-Aminolevulinic Acid

Study type

Interventional

Funder types

Other

Identifiers

NCT01502605

J1140

Details and patient eligibility

About

This research is being done to study the safety and utility of 5-aminolevulinic acid (5-ALA) (also known as Gliolan) for identifying brain tumor tissue during surgery. The goal of this study is to determine if 5-ALA can differentiate between tumor and normal brain tissue.

Sometimes, during brain surgery, the removal of tumor tissue can be difficult because the tumor can look like normal brain tissue. Studies in other countries have shown that in some brain tumors, 5-ALA can make the tumors appear brighter under ultraviolet light. This may make it easier for doctors to remove as much tumor as safely as possible from your brain.

This study also hopes to see if 5-ALA can find different cell populations within the tumor that is removed and allow the researchers to better understand brain tumors.

The purpose of this study is to:

Find out how well 5-ALA can separate normal brain tissue from tumor tissues AND to see how well 5-ALA can find different cell populations within brain tumors
Identify the amount of 5-ALA that should be taken before surgery to make the tumors glow under ultraviolet light
Make sure the 5-ALA identifies tumor and not normal brain
Make sure 5-ALA does not cause any side effects

Enrollment

6 patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Patients must have clinically documented primary brain tumor for which resection is clinically indicated. Radiographic findings should be consistent with high grade glioma. Intraoperative frozen section should either be: anaplastic astrocytoma (WHO Grade III astrocytoma) or glioblastoma (WHO Grade IV astrocytoma).
Patients must be aged greater than 18 years old
Karnofsky Performance Score > 70 (Appendix)
Patients must have normal organ and marrow function as defined below:
- Leukocytes > 3,000 /uL
- Absolute neutrophil count > 1,500/uL
- Platelets > 100,000/uL
- Total bilirubin within normal institutional limits
- AST/ALT within normal institutional limits
- Creatinine within normal institutional limits

Exclusion criteria

Prior craniotomy for resection, deep seated tumors in thalamus and brain stem.
History of allergic reactions to compounds of similar chemical composition to ALA.
Personal or family history of porphyrias
Personal history of hepatitis or other liver diseases.
Pregnant women are excluded from this study because ALA is of unknown teratogenic effects. Because there is an unknown but potential risk for adverse events in nursing infants secondary to treatment of the mother with ALA, breastfeeding should be discontinued prior to treatment with ALA.
Inability to undergo magnetic resonance imaging (i.e. those patients with AICD/pacemakers).