Phase II Study of Intensity Modulated Radiotherapy in Dose Painting for Sinus Carcinomas After Endoscopic Surgery (SinocaRT)

Centre Francois Baclesse

Status and phase

Enrolling

Phase 2

Conditions

Tumor, Solid

Treatments

Radiation: Radiotherapy in painting dose on histoscannographic mapping

Radiation: Standard pan-sinusal Radiotherapy

Study type

Interventional

Funder types

Other

Identifiers

2022-A02011-42

Details and patient eligibility

About

The patient is randomized to one of the following groups:

Enrollment

52 estimated patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Patients >18 years of age
Patient with a histologically confirmed malignant tumor of the sinuses, any histological type except melanoma, lymphoma, mesenchymal tumors (sarcoma)
Patient treated by endoscopic sinonasal surgery with histosurgical mapping within 2 months prior to radiotherapy
Indication for radiotherapy treatment (photontherapy or protontherapy), without neoadjuvant chemotherapy (concomitant chemotherapy is permitted)
Signature of informed consent prior to any specific study procedure
Subject affiliated to a social security system

Exclusion criteria

Patient with not operated in place tumor
Patient with distant metastases
Patient treated with neoadjuvant chemotherapy
Pregnant or breast-feeding woman or absence of contraception during genital activity
History of any other malignant disease in the last 3 years, except basal cell skin cancer, carcinoma in situ or superficial bladder tumor. Any other solid tumor or lymphoma (without bone marrow involvement) must have been treated and show no sign of recurrence for at least 3 years.
Simultaneous participation in another therapeutic clinical trial
Patients deprived of their liberty, under guardianship, under curatorship, or subject to a legal protection measure, or unable to express their consent.
Patients unable to undergo trial monitoring for geographical, social or psychopathological reasons