Phase II Study of Refametinib, a MEK Inhibitor, as Second-line Treatment in Advanced Biliary Tract Adenocarcinoma

Samsung Medical Center

Status and phase

Completed

Phase 2

Conditions

Biliary Tract Cancer

Treatments

Drug: refametinib

Study type

Interventional

Funder types

Other

Identifiers

NCT02346032

2014-07-148

Details and patient eligibility

About

Phase II Study of Refametinib, a MEK inhibitor, as second-line treatment in advanced biliary tract adenocarcinoma

Full description

Refametinib will be administered orally at the starting dose of 50 mg twice daily on a continuous daily dosing schedule.

Self-administration of refametinib tablets will take place on an outpatient basis. Patients experiencing dose-limiting toxicity attributed to study medication should have at least 1-week treatment breaks inserted into the continuous daily dosing period as needed and/or may be interrupted or reduced depending on individual tolerability.

Enrollment

4 patients

Sex

All

Ages

20+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

age ≥ 18
histologically or cytologically confirmed adenocarcinoma of biliary tract
unresectable or metastatic
ECOG performance status of 0~2
measurable lesion per RECIST 1.1 criteria
adequate marrow, hepatic, renal functions
normal range of cardiac function confirmed by echocardiogram within 1 year (LVEF ≥50)
Child-Pugh Class A in case of liver cirrhosis
One prior treatment of cytotoxic chemotherapy (including adjuvant treatment within 12 months)
Resolution of all acute toxic effects of any prior therapy to Common Toxicity Criteria for Adverse Events (CTCAE 4.03) ≤ grade 1.
provision of a signed written informed consent

Exclusion criteria

History of cardiac disease
Ongoing infection > Grade 2 according to NCI-CTCAE version 4.03. Hepatitis B is allowed if no active replication (defined as abnormal ALT >2xULN associated with HBV DNA >20,000 IU/mL) is present
Severe co-morbid illness and/or active infections including active hepatitis C and human immunodeficiency virus (HIV) infection
History of interstitial lung disease (ILD).
Any cancer curatively treated < 3 years prior to study entry, except cervical carcinoma in situ, treated basal cell carcinoma, and superficial bladder tumors (Staging: Ta, Tis and T1).
Renal failure requiring hemo- or peritoneal dialysis.
Clinically significant GI bleeding (CTCAE 4.03 grade 3 or higher) within 30 days prior to start of screening
Thrombotic or embolic events such as cerebrovascular accident (including transient ischemic attacks) within 6 months prior to start of screening.
History of organ allograft, cornea transplantation will be allowed
Active CNS metastases not controllable with radiotherapy or corticosteroids
Visible retinal pathology as assessed by ophthalmologic exam that is considered a risk factor for RVO or CSR.
Known history of hypersensitivity to study drugs
Any condition that was unstable or which could jeopardize the safety of the patient and his/her compliance in the study
Non-healing wound, ulcer, or bone fracture.
Patients with seizure disorder requiring medication.
Use of strong inhibitors of CYP3A4 and strong inducers of CYP3A4 should be stopped 2 weeks before start of screening (see Appendix 1).
Acute steroid therapy or taper for any purpose (chronic steroid therapy is acceptable provided that the dose is stable for 1 month before start of screening and thereafter).
Substance abuse, medical, psychological or social conditions that may interfere with the patient's participation in the study or evaluation of the study results.
Pregnant or lactating women. Women of childbearing potential not employing adequate contraception. Women of childbearing potential must have a negative serum pregnancy test performed within 7 days prior to start of study treatment and a negative result must be documented before first dose of study drug.