Phase II Study of Safety and Feasibility of Intensive Blood Glucose Control With Insulin on Acute Medical Wards (IPS2008)

St George's, University of London

Status and phase

Completed

Phase 2

Conditions

Hyperglycemia

COPD

Treatments

Drug: Insulin

Study type

Interventional

Funder types

Other

Identifiers

NCT00764556

EudraCT 2007-004956-35

SGH-ClinPharm-1

Ethics 07/H0715/93

Details and patient eligibility

About

Patients with chronic obstructive pulmonary disease (COPD) are commonly admitted to hospital with exacerbations of their lung disease. A combination of the acute illness and treatment with oral steroids causes a rise in blood sugar. Patients with high blood sugar do worse than those with normal blood sugar. The aim of this study is to develop a safe and effective protocol for tight control of blood glucose with insulin on acute medical wards outside the intensive care environment. This will allow us to perform a formal trial to determine whether blood glucose control with insulin reduces death and complications from COPD exacerbations.

Enrollment

20 patients

Sex

All

Ages

40+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Physician diagnosis of AECOPD as primary cause for admission
Able to enter study within 24 hours of admission

Exclusion criteria

Intensive care unit admission
Moribund or not for active treatment
Admission expected to last <48 hours
Unable or unwilling to give informed consent
Known Type I diabetes mellitus
Patients with reduced awareness of hypoglycaemia including reduced Glasgow coma scale or those taking beta blockers
Patients with renal or hepatic failure at increased risk of hypoglycaemia