Phase II Study of Stereotypes and Mental Retardation: Neurobiological Basis

United States Department of Health and Human Services (HHS)

Status and phase

Suspended

Phase 2

Conditions

Stereotyped Behavior

Mental Retardation

Treatments

Drug: bromocriptine

Drug: sertraline hydrochloride

Study type

Interventional

Funder types

Other

NIH

Identifiers

NCT00004300

199/11754

UF-63394

Details and patient eligibility

About

OBJECTIVES: I. Determine differences between persons with repetitive behavior disorders and matched controls on measures of motor control relevant to basal ganglia pathophysiology.

II. Determine the efficacy of bromocriptine, a dopamine agonist, in the treatment of stereotyped behavior and related behavior disorders.

III. Determine the efficacy of sertraline hydrochloride, a selective serotonin uptake inhibitor, in the treatment of repetitive behavior disorders.

IV. Identify behavioral, environmental, and biological variables with differential drug treatment response.

Full description

PROTOCOL OUTLINE: Motor slowness (bradykinesia) and motor control are tested in repetitive behavior disorder patients and matched controls. Group differences reflecting alterations in basal ganglia dopamine function are compared.

Behavioral assessments are conducted on each patient by trained observers. Assessments are taken at baseline and during the maintenance phase of drug treatment described below.

The efficacy of bromocriptine in the treatment of stereotypy and self-injury is determined in a randomized, double blind, placebo controlled, crossover study extending over 20 weeks. Cohorts of 6 to 8 patients first enter into a single blind placebo phase, followed by double blind treatment with placebo or bromocriptine. The crossover manipulation entails a titration phase, a maintenance phase, then a final single blind placebo condition.

The same experimental design is used to determine the efficacy of sertraline or placebo in the treatment of stereotypy and concomitant self injury and compulsions. Duration of study is 26 weeks.

Sex

All

Ages

18 to 55 years old

Volunteers

Accepts Healthy Volunteers

Inclusion and exclusion criteria

PROTOCOL ENTRY CRITERIA:

--Disease Characteristics--

Diagnosis of mental retardation
High rate of stereotyped behavior, such as concomitant self-injurious and compulsive behaviors
No diagnosis of tardive dyskinesia or akathisia

--Prior/Concurrent Therapy--

No exposure to neuroleptics within 6 months prior to study

--Patient Characteristics--

Age: 18 to 55
Hematopoietic: (for bromocriptine and sertraline treatments) No history of anemia No clinically significant hematologic disease
Hepatic: (for bromocriptine and sertraline treatments) No history of hepatic abnormalities No clinically significant liver disease
Renal: (for bromocriptine and sertraline treatments) No history of renal abnormalities No clinically significant renal disease
Cardiovascular: (for bromocriptine and sertraline treatments) No history of hypertension No clinically significant cardiac disease
Other: No history of seizure within 4 months prior to study (for bromocriptine and sertraline treatments) No history of sensitivity to ergot alkaloids (for bromocriptine treatment) No sensitivity to serotonin uptake inhibitors (for sertraline treatment) No patients with sensory deficits (for motor function assessments)