Phase II Trial of Aprepitant & Palonosetron for CINV Prevention w FOLFOX
Status and phase
Conditions
Treatments
Study type
Funder types
Identifiers
Details and patient eligibility
About
RATIONALE: Aprepitant, palonosetron, and dexamethasone may help lessen or prevent nausea and vomiting in patients receiving chemotherapy.
PURPOSE: This phase II trial is studying how well giving aprepitant together with palonosetron and dexamethasone works in preventing nausea and vomiting caused by chemotherapy in patients receiving chemotherapy for metastatic colorectal cancer.
Full description
OBJECTIVES:
Primary
- Evaluate the efficacy, in terms of nausea and vomiting control, of aprepitant, palonosetron hydrochloride, and dexamethasone, in preventing chemotherapy-induced nausea and vomiting in patients receiving FOLFOX or FOLFIRI chemotherapy for metastatic colorectal cancer.
Secondary
- Assess the percentage of patients with no emesis and no rescue therapy when treated with aprepitant, palonosetron hydrochloride, and dexamethasone during repeated courses of FOLFOX or FOLFIRI chemotherapy.
- Assess the effects of aprepitant on nausea, appetite, taste changes (via visual analogue scale), nutritional intake, and mucositis in these patients.
- Assess the safety of this regimen in these patients.
OUTLINE: This is an open-label, multicenter study.
Beginning 1 hour prior to the initiation of chemotherapy on day 1, patients receive oral aprepitant on days 1-3, oral dexamethasone on days 1-4, and palonosetron hydrochloride IV on day 1.
Nausea is assessed daily for up to 4 courses of chemotherapy.
Quality of life is assessed at baseline.
PROJECTED ACCRUAL: A total of 100 patients will be accrued for this study.
Enrollment
Sex
Ages
Volunteers
Inclusion and exclusion criteria
DISEASE CHARACTERISTICS:
-
Diagnosis of colorectal cancer
-
Metastatic disease
-
Scheduled to receive 1 of the following chemotherapy regimens*:
- FOLFOX 4 (oxaliplatin, fluorouracil, leucovorin calcium)
- FOLFOX 6
- FOLFOX 7
- FOLFIRI (irinotecan hydrochloride, fluorouracil, leucovorin calcium) NOTE: *Regimens may also include cetuximab or bevacizumab
-
No emesis and no requirement for antiemetic agents within 48 hours prior to beginning chemotherapy
- Single-agent benzodiazepines as a hypnotic allowed
-
No chronic nausea
PATIENT CHARACTERISTICS:
- Eastern Cooperative Oncology Group (ECOG) performance status 0-2
- Life expectancy > 4 months
- White Blood Cell(WBC)count > 3,000/mm^³
- Absolute neutrophil count (ANC) > 1,500/mm^³
- Platelet count > 100,000/mm^³
- Bilirubin ≤ 2.5 times upper limit of normal (ULN) (< 5 times ULN if liver metastases present)
- Creatinine ≤ 1.5 times ULN
- Aspartate aminotransferase(AST) or Alanine aminotransferase (ALT) ≤ 2.5 times ULN (< 5 times ULN if liver metastases present)
- Able to swallow tablets and capsules
- No known sensitivity to aprepitant, palonosetron hydrochloride, or dexamethasone
- Not pregnant or nursing
- Negative pregnancy test
- No history of consuming ≥ 5 alcoholic drinks/day within the past year
- No concurrent illness requiring systemic corticosteroids other than planned dexamethasone during study treatment
- No clinical signs of active systemic infection involving the gastrointestinal tract
- No active bowel obstruction
PRIOR CONCURRENT THERAPY:
-
See Disease Characteristics
-
No prior chemotherapy > Hesketh level 3
- Prior fluorouracil with or without leucovorin calcium or capecitabine allowed
-
At least 30 days since prior investigational drugs
-
At least 14 days since prior neurokinin-1 antagonists
-
Concurrent hydrocortisone at physiologic replacement doses (≤ 30 mg/day) allowed
-
No concurrent chronic antiemetic agents
-
Concurrent hypnotics allowed
-
Concurrent rescue antiemetics allowed
Trial design
Primary purpose
Allocation
Interventional model
Masking
54 participants in 1 patient group
Trial contacts and locations
Loading...
Data sourced from clinicaltrials.gov
Clinical trials
Research sites
Resources
Legal