Phase II Trial of RA-18C3 in Subjects With Moderate to Severe Acne Vulgaris

Janssen (J&J Innovative Medicine)

Status and phase

Completed

Phase 2

Conditions

Acne Vulgaris

Treatments

Drug: RA-18C3

Study type

Interventional

Funder types

Industry

Identifiers

NCT01474798

2011-PT020

Details and patient eligibility

About

This is a 91-day phase II, open label trial of the true human monoclonal antibody RA-18C3 in subjects with moderate to severe acne vulgaris. Ten (10) subjects will receive RA-18C3 via subcutaneous injection. Subjects will receive injections at Days 0, 21, and 42 for a total of 3 injections. Study drug will be administered under close observation in a facility equipped to handle medical emergencies. Subjects will not be discharged from the facility until at least 1 hour following the injection or 1 hour after their vital signs have stabilized. Safety will be assessed by pre- and post-treatment serial measurements of vital signs, clinical laboratory assessments, and the recording of adverse clinical events.

Enrollment

11 patients

Sex

All

Ages

18 to 30 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Age: ≥ 18
Moderate to moderately severe inflammatory acne vulgaris:
- Investigator's Global Assessment grade of ≥ 3 and,
- ≥ 15 inflammatory lesions (no more than 6 nodules) and,
- ≥ 15 non-inflammatory lesions
Four week washout period for topical and oral antibiotic treatment
Four week washout period for topical retinoids
Negative pregnancy test at screening and at specified time points throughout the trial. For subjects with reproductive potential, a willingness to utilize contraception during the study and including 3 months after study completion. Sexually active men must use an accepted method of contraception during the study and including 3 months after study completion.
Subjects weighing ≥ 27 kg
Signed and dated Institutional Review Board (IRB) approved informed consent before any protocol-specific screening procedures are performed

Exclusion criteria

A diagnosis of Acne conglobata, acne fulminans, secondary acne, severe nodulocystic acne requiring treatment with isotretinoin, or other dermatologic conditions requiring interfering phototherapy, topical, or systemic treatment.
Treatment with any biologicals or investigational agents within the last 4 weeks (or 5 half-lives, whichever is longer).
Men with facial hair that would interfere with assessments
History of uncontrolled diabetes, unstable ischemic heart disease, active inflammatory bowel disease, active peptic ulcer disease, recent stroke (within 3 months), ongoing congestive heart failure, and any other condition which, in the opinion of the investigator, would put the subject at risk by participation in the protocol.
Hemoglobin <10.0 g/dL, or WBC <3.0 x 103/mm3, or platelet count <125 x 103/mm3, or creatinine > 1.5mg/dL, or AST/ALT >2 x ULN, or alkaline phosphatase >2 x ULN
Known HIV antibody, hepatitis B surface antigen and/or hepatitis C antibody.
History of malignancy within 5 years prior to study entry other than carcinoma in situ of the cervix, or adequately treated, non-metastatic squamous or basal cell carcinoma of the skin.
History of severe allergic or anaphylactic reactions to humanized or murine monoclonal antibodies.
History of tuberculosis (latent or active) or positive Interferon-gamma release assay (IGRA)
Infectious disease:
- CRP >30 mg/L, fever, or infection requiring treatment with antibiotics within 3 weeks prior to Screening
Immunodeficiency
Female subjects who are pregnant, planning to become pregnant during the course of the study, or breast-feeding
Receipt of a live (attenuated) vaccine within 1 month prior to Screening
Major surgery within 28 days prior to Day 0
Participation in an investigational drug or device trial within 30 days prior to Screening