Phase III PEG-Intron in HIV-infected Patients (Study P00738)

Merck Sharp & Dohme (MSD)

Status and phase

Completed

Phase 3

Conditions

AIDS

HIV Infections

Treatments

Drug: PEG-Intron

Study type

Interventional

Funder types

Industry

Identifiers

NCT00035360

P00738

Details and patient eligibility

About

This is a randomized, double-blind, multicenter trial testing 2 doses of PEG-Intron, 1.0mcg/kg/week and 3.0mcg/kg/week in heavily treatment-experienced HIV-infected patients compared to placebo. The study will evaluate the efficacy and safety of PEG-Intron when added to stable optimized background antiretroviral therapy in this patient population.

Full description

This study will randomize 675 patients (225 in each of the 3 arms) to either: PEG-Intron 1mcg; 3mcg or Placebo, at 90 centers worldwide. Each center will enroll approximately 10 patients.

Study drug will be added to optimized background anti-retroviral therapy of patients whose HIV RNA is incompletely suppressed by their therapy (HIV RNA 400-50,000 copies/ML) after 2-6 months.

A single dose reduction of 50% will be allowed for toxicity. An Interim Analysis will be conducted when 50% of patients have completed 24 weeks of therapy. The study treatment phase will be 48 weeks with monthly visits for virologic virologic and safety monitoring. The primary endpoint is change in HIV RNA from baseline to week to assess efficacy. Durability of response will be assessed at 48 weeks.

Enrollment

49 patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

HIV positive
History of virologic failure on at least 2 antiretroviral regimens including exposure to at least one NRTI, one NNRTI and one PI
HIV RNA >400-<50,000 copies/mL
Laboratory parameters: platelet count (75,000u/L, hemoglobin >9gm/dl, absolute neutrophil count >1,000/uL, SGOT/SGPT<5xULN.

Exclusion criteria

Current ribavirin therapy
Subjects with a recent diagnosis or history of moderate or severe depression requiring ongoing psychiatric intervention
Females of childbearing potential who are breastfeeding, who are pregnant, or not using adequate birth control measures
Concomitant use of immunosuppressants or cytotoxic agents
History of seizure disorder requiring use of anticonvulsants