Phase IV Randomization to On-Going Treatment to Evaluate Sustained Sorafenib

Bayer

Status and phase

Terminated

Phase 4

Conditions

Carcinoma, Renal Cell

Treatments

Drug: Gemcitabine or Interferon (only)

Drug: Nexavar (Sorafenib, BAY43-9006) with addition of gemcitabine or interferon

Study type

Interventional

Funder types

Industry

Identifiers

NCT00352859

12178

Details and patient eligibility

About

The purpose of this study is to see if taking interferon or gemcitabine along with sorafenib will stop the advanced renal cell cancer from becoming worse in some people. To do this, sorafenib along with gemcitabine or interferon will be compared to treatment with gemcitabine or interferon alone. More safety information on sorafenib will be also collected. About 260 patients with progressed renal cell cancer will be in this study.

Enrollment

2 patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Male or female patients above 18 years of age with advanced RCC who have received sorafenib as their first and only systemic anti-tumor therapy for RCC prior to randomization
Patients must have previously tolerated a minimum dose of sorafenib 400 mg daily for at least six weeks prior to study entry and have radiographically documented progressive disease while on sorafenib
Patients must have experienced clinical benefit, partial response, complete response or stable disease during their previous course of sorafenib therapy
Life expectancy > 12 weeks
Patients must meet the Memorial Sloan-Kettering Cancer Center (MSKCC) risk category of low or medium at randomization
Patients must give written informed consent prior to any study specific screening procedures with the understanding that the patient has the right to withdraw from the study at any time, without prejudice
Patients must have at least one uni-dimensional measurable lesion by CT-scan or MRI according to Response Evaluation Criteria in Solid Tumors (RECIST)
Patients must not have brain metastases
Eastern Cooperative Oncology Group (ECOG) Performance Status of 0 to 1
In addition, the following patients may be included, provided all other inclusion and exclusion criteria are met
- Patients who have received the vaccines cG250 (monoclonal antibody to carbonic anhydrase IX) or HSPPC-96 (Heat Shock Protein Peptide Complex 96) are eligible provided that they have received no other systemic anti-cancer therapy
- Patients who were enrolled in the ARCCS treatment protocol

Exclusion criteria

Patients must not have experienced more than three weeks from documented disease progression to randomization
Any medical condition requiring the use of systemic corticosteroids during IFN therapy
Previous or concurrent cancer that is distinct in primary site or histology from the cancer being evaluated in this study EXCEPT cervical carcinoma in situ, treated basal cell carcinoma, superficial bladder tumors (Ta, Tis & T1) or any cancer curatively treated within the last three years prior to study entry
Severe renal impairment or receiving dialysis
More than a two week interruption in sorafenib dosing immediately prior to randomization
Patients with a best response of disease progression on their previous course of sorafenib
Patients who meet the MSKCC high risk category at randomization
Hemorrhagic episode >= Grade 2 NCI CTC AE v3.0 within last six months
History of cardiac disease: congestive heart failure> NYHA class 2; active cardiovascular disease (MI more than six months prior to study entry is allowed); cardiac arrhythmia requiring anti-arrhythmic therapy (beta blockers or digoxin are permitted) or uncontrolled hypertension
Active clinically serious bacterial or fungal infections (>= Grade 2 NCI CTCAE v3.0)
Known history of Human Immunodeficiency Virus (HIV) infection or chronic hepatitis B or C
Symptomatic metastatic brain or meningeal tumors unless the patient is > six months from definitive therapy, has a negative CNS imaging study within four weeks of study entry, and is clinically stable off steroids. The patient must not be undergoing acute steroid taper
Patients with seizure disorder requiring medication (such as steroids or anti-epileptics)
Ongoing substance abuse, medical, psychological or social conditions that may interfere with the patients participation in the study or evaluation of the study results
Known or suspected allergy to the investigational agent or any agent given in association with this trial, including history of sensitivity to E. coli-derived products
Any condition that is unstable or that could jeopardise the safety of the patient and his/her compliance in the study. Patients with a history of severe depression; patients with clinically significant active autoimmune disorders; history of organ allograft
Pregnant or breast-feeding patients. Women of childbearing potential must have a negative pregnancy test performed within seven days of the start of study treatment. Both men and women enrolled in this trial must use adequate birth control measures during the course of the trial
Patients who have had a significant surgical procedure within the past four weeks are excluded

Excluded Therapies and Medications, Previous and Concomitant:

Any prior or concurrent systemic anti-cancer therapy including chemotherapy, monoclonal antibodies, hormonal therapy or investigational therapy, except for bisphosphonates and sorafenib
Biological response modifiers, such as G-CSF or GM-CSF, within three weeks prior to study entry or during study. G-CSF and other hematopoietic growth factors may only be used in the management of acute toxicity such as febrile neutropenia when medically indicated or at the discretion of the Investigator. However, they may not be substituted for a required dose reduction of any study drug
Patients taking erythropoietin are permitted provided no dose adjustment is undertaken within two months prior to the study or during the study
Concomitant rifampicin or St. John's Wart
Palliative therapy will be allowed, patients may receive palliative and supportive care for any underlying illness