Phase Locked TRanscranial Electrical EXcitation (T-REEX)

Stichting IMEC-NL

Status

Enrolling

Conditions

Novel Method for Transcranial Brain Stimulation

Treatments

Device: T-REEX algorithm

Study type

Interventional

Funder types

Other

Identifiers

NCT05847829

NL82733.015.22

Details and patient eligibility

About

Transcranial current stimulation (tCS) has been extensively studied due to its potential of selectively stimulate brain regions in a non-invasive way. However, classic stimulation paradigms are often applied in an open loop configuration, without considering the effects on the underlying brain activity.

Recent studies suggest that when alternating current are used, it would be beneficial to phase lock the stimulation to the target brain wave of interest to achieve selective temporal stimulation, allowing for better control over the stimulation effects.

This study aims at demonstrating a novel setup that allows for precise stimulation targeted in space and time. To achieve that, a combination of tCS and (EEG phased locked) closed-loop modality are used to obtain the required selectivity.

Enrollment

10 estimated patients

Sex

All

Ages

18 to 64 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Signed informed consent
Age between 18 and 64

Exclusion criteria

Wounded or particular sensitive skin at areas of investigation. For example, skinrash, discoloration, scars, or open wounds
Allergies to adhesive or dry electrodes or silver chloride
Pregnant or lactating
Any of the following symptoms (fever, tiredness, dry cough, aches and pains, nasal congestion, runny nose, sore throat, diarrhoea)
Known neurological disorders
Previous epileptic episodes
Active implants such as pacemakers or brain stimulators
Intracranial metal implants