Phenolic-rich Oats and Artery Improvement (PROGRAIN2)
Status
Conditions
Treatments
Details and patient eligibility
About
In this proposed human trial, the investigators aim to establish whether consumption of one portion of phenolic acid-rich oats leads to acute improvements (i.e. 1-24h post-intake) in markers of cardiovascular disease risk relative to an energy matched control intervention in healthy men with high-normal to mildly elevated blood pressure.
Full description
A diet rich in whole grain is inversely associated with cardiovascular disease risk. Whole grains contain a wide range dietary components including potentially vasoactive phenolic acids.
Enrollment
Sex
Ages
Volunteers
Inclusion criteria
- Above average blood pressure (i.e. systolic 120-159 mmHg and diastolic 75-99 mmHg)
Exclusion criteria
- Abnormal biochemical, haematological results as assessed at health screening
- Hypertension (i.e. systolic/diastolic blood pressure ≥160/100 mm Hg) BMI >35
- Current smoker or ex-smoker ceasing <3 months ago
- Past or existing medical history of vascular disease, diabetes, hepatic, renal, gastrointestinal, haematological, neurological, thyroidal disease or cancer
- Prescribed or taking lipid lowering, antihypertensive, vasoactive (e.g. Viagra), anti-inflammatory, antibiotic or antidepressant medication
- Allergies to whole grains
- Parallel participation in another research project
- Having flu vaccination or antibiotics within 3 months of trial start
- On a weight reduction regime or taking food supplements within 3 months of trial start
- Performing high level of physical activity (i.e. >3 x 20 min aerobic exercise/week)
- Consumption of ≥21 units of alcohol/week
- Small veins not allowing cannulation
Trial design
Primary purpose
Allocation
Interventional model
Masking
18 participants in 2 patient groups, including a placebo group
Trial contacts and locations
Loading...
Data sourced from clinicaltrials.gov
Clinical trials
Research sites
Resources
Legal