Phenotype and Multi-omics Analysis of Children With Congenital Diarrhea and Enteropathy in China

Fudan University

Status: Enrolling

Conditions: Diarrhea Infantile

Study type: Observational

Funder types: Other

Identifiers

NCT06356545

OMICS_CODE_01

Details and patient eligibility

About

This study will establish a clinical cohort of children with congenital diarrhea and enteropathy (CODE), mine biomarkers of CODE through multi-omics technology and construct a clinical risk prediction model.

Full description

This study will establish a clinical cohort and a clinical phenotype database of children with congenital diarrhea and enteropathy (CODE), The investigator will mine biomarkers of CODE through multi-omics technology. This study is designed to construct a clinical risk prediction model by combining artificial intelligence technology.

Enrollment: 60 estimated patients

Sex: All

Ages: 1 month to 3 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Patients with chronic diarrhea lasting greater than 2 months or greater than 1 month in patients younger than 2 months of age
• Patients with consent from parents or legal guardians

Exclusion criteria

• Chronic diarrhea caused by specific infections, i.e. CMV, Clostridioides difficile
• Chronic diarrhea with necrotizing enterocolitis, short bowel syndrome
• Functional diarrhea
• Patients with poor compliance

Trial design

60 participants in 2 patient groups

Case

Description:

Congenital diarrhea and enteropathy (CODE) patients

Control

Description:

Healthy children