Phenotypes of Preschool Wheezing Among Children Attending Sohag University Hospital

Sohag University

Status: Enrolling

Conditions: Wheezing

Treatments: Radiation: Chest x- Rays

Study type: Observational

Funder types: Other

Identifiers

NCT06603584

soh-Med-24-06-20MS

Details and patient eligibility

About

Wheezing in preschool children is very common, with a wide differential diagnosis. It is essential to be sure of the exact sound that parents are describing; the term 'wheeze' is often applied to non-specific sound.Approximately one-third of children are diagnosed with wheeze in the first 3 years of life, making wheeze one of the commonest respiratory symptoms.The differential diagnosis of wheeze is wide, and different management strategies are needed depending on the underlying phenotype. The word 'wheeze' is used to describe many different sounds. That can be heard by both clincians and parent. Even if true wheeze is heard, this should not be automatically assumed to be due to bronchospasm. Airway narrowing by mucus will produce true wheeze but does not respond to bronchodilators. Similarly, airway malacia, either related to intrinsic airway wall defects or loss of alveolar tethering points, are also causes of bronchodilatorunresponsive wheeze; indeed, bronchodilators, by reducing airway smooth muscle tone, may actually worsen airway narrowing.

Enrollment: 100 estimated patients

Sex: All

Ages: 2 to 6 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• patients from the age of one to five years with recurrent wheezing

Exclusion criteria

• Children above 5 years and below one year old.
• Failure to obtain informed consent.
• Children below 6 years with chest diseases other than wheezing

Trial design

100 participants in 4 patient groups

group A

Description:

Bronchial Asthma

Treatment:

Radiation: Chest x- Rays

group B

Description:

Chronic Aspiration

Treatment:

Radiation: Chest x- Rays

group C

Description:

Primary Ciliary Dyskinesia

Treatment:

Radiation: Chest x- Rays

group D

Description:

Cystic Fibrosis

Treatment:

Radiation: Chest x- Rays