Phenotypic Heterogeneity in Hemophilia A: An Investigation of the Role of Platelet Function

CancerCare Manitoba

Status: Completed

Conditions: Hemophilia A

Study type: Observational

Funder types: Other; Industry

Identifiers

NCT02225483

H2013:304

Details and patient eligibility

About

The is study will examine whether variation in clinical bleeding frequency and severity among boys with severe Hemophilia A (Factor VIII deficiency) is associated with variations in laboratory measurements of platelet activity.

Enrollment: 42 patients

Sex: Male

Ages: 3 to 20 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• documented circulating FVIII level of ≤1%
• age 3 - 20 years
• may be on primary or secondary prophylaxis
• granting of informed consent

Exclusion criteria

• measurable inhibitor level at the time of enrollment
• ingestion of aspirin/supplement known to influence platelet function within 14 days of blood sampling, or ibuprofen within 3 days

Trial design

42 participants in 1 patient group

Hemophilia A

Description:

Boys with Factor VIII coagulant activity less than or equal to 1%.