Phenotyping and Genotyping of Duffy Antigen (DARC)

University Hospital, Strasbourg, France

Status: Completed

Conditions: Plasmodium Vivax

Study type: Observational

Funder types: Other

Identifiers

NCT05527119

8543

Details and patient eligibility

About

Malaria remains the world's leading parasitic endemic. Almost half of the world's population lives in endemic areas. Many at-risk people in African countries remain without access to malaria control. Malaria kills approximately 400,000 people each year, most of whom are children under the age of 5 in Africa. Since 2005, an increasing number of Plasmodium vivax infections have been observed in Duffy-negative populations in South America and Africa, calling into question the essential role of the PvDBP-DARC interaction. The objective of the investigators is therefore to study and understand the invasion pathways used by Plasmodium vivax in Duffy-negative subjects.

Enrollment: 30 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Major subjects
• with malaria and willing to have their blood samples analyzed for this research

Exclusion criteria

• Subjects refusing to participate in the study