Phenylephrine Versus Norepinephrine in Septic Shock

University of Roma La Sapienza

Status and phase: Completed; Phase 2

Conditions: Septic Shock

Treatments: Drug: Phenylephrine

Study type: Interventional

Funder types: Other

Identifiers

NCT00481442

1125

Details and patient eligibility

About

Clinical studies evaluating the clinical use of phenylephrine in septic shock are lacking. The present study was designed to compare the effects of norepinephrine and phenylephrine on systemic and regional hemodynamics in patients with catecholamine-dependent septic shock.

Enrollment: 15 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Clical diagnosis of Septic Shock
• norepinephrine to maintain mean arterial pressure between 65 and 75 mmHg despite adequate volume resuscitation (pulmonary artery occlusion pressure = 12-18 mmHg and central venous pressure = 8-12 mmHg).

Exclusion criteria

• Age < 18 years
• Pregnancy
• Present or suspected acute coronary artery disease
• Present or suspected acute mesenteric ischemia.

Trial design

Primary purpose: Treatment

Allocation: Non-Randomized

Interventional model: Crossover Assignment

Masking: None (Open label)