Phosphorous Magnetic Resonance Spectroscopy of Heart

The Washington University

Status: Completed

Conditions: Left Ventricular Dysfunction

Treatments: Diagnostic Test: MR Spectroscopy

Study type: Interventional

Funder types: Other

Identifiers

NCT01110395

09-0533

Details and patient eligibility

About

Heart needs constant supply of energy to continue working. Phosphorus magnetic resonance spectroscopy allows us to measure energy produced in the heart. The purpose of this study is to determine if the energy production is reduced in failing heart.

Full description

We will use non-invasive phosphorus magnetic resonance spectroscopy technique to measure creatine kinase (CK) flux in failing heart. The studies will be done on Siemens 3.0T human system. We will recruit subjects with LV dysfunction due to prior anterior wall myocardial infarction.

Enrollment: 15 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Individuals with left ventricular dysfunction

Exclusion criteria

• Age < 18, pregnant, history of excessive alcohol use, or any condition (e.g. claustrophobia, a pacemaker) that would prevent him/her from completing the magnetic resonance spectroscopy study

Trial design

Primary purpose: Basic Science

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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15 participants in 1 patient group

MR Spectroscopy Post-Heart Transplant

Experimental group

Description:

Patients post heart transplant getting heart biopsy

Treatment:

Diagnostic Test: MR Spectroscopy