Photobiomodulation and Parkinson

University of Oviedo

Status: Completed

Conditions: Parkinson Disease

Treatments: Other: Transcranial photobiomodulation

Study type: Interventional

Funder types: Other

Identifiers

NCT03811613

#08/18

Details and patient eligibility

About

This study aimed to assess the effects of transcranial photobiomodulation in patients with Parkinson's disease (PD).

Full description

Thirty-five patients with idiopathic PD were randomly assigned to a photobiomodulation (n=17, [mean±SD] 72±7 years) or sham group (n=18, 70±8 years) during 9 weeks (2 sessions/week). The primary endpoint was the motor portion of the Movement Disorders Society-United PD Rating Scale. Secondary endpoints were the Scales for Outcomes in PD, static posturography, walking ability (ten-meter walk test [TMWT]) and functional mobility (timed up and go [TUG] test).

Enrollment: 35 patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

• Having been diagnosed with idiopathic PD.
• Stage 1-2 on the Hoehn and Yahr Scale.
• Having no neurological condition other than PD.
• Being able to stand for 2 minutes and walk 10 meters without assistance.
• Having no severe dyskinesias or "ON-OFF" phases.

Exclusion criteria

• Do not follow inclusion criteria.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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35 participants in 2 patient groups

Photobiomodulation group

Experimental group

Description:

17 Parkinson´s disease patients were randomly assigned to the photobiomodulation group (experimental group). Intervention: Photobiomodulation was administered using red light-emitting diodes (LEDs) with a 670-nm wavelength in six 1-minute blocks alternating the LEDs between the right and left temples, with a 30-second rest between blocks.

Treatment:

Other: Transcranial photobiomodulation

Sham group

Sham Comparator group

Description:

18 Parkinson´s disease patients were randomly assigned to the sham group. Intervention: Procedures for the sham group were identical as the photobiomodulation one, except that patients received photobiomodulation during only 5 seconds followed by 55 seconds with no treatment (equalling 1/12th of the energy used for the intervention group).

Treatment:

Other: Transcranial photobiomodulation