Photodynamic Therapy During Supportive Periodontal Therapy

National University of Singapore

Status and phase: Completed; Phase 4

Conditions: Periodontal Attachment Loss; Periodontal Diseases; Chronic Periodontitis

Treatments: Other: Scaling and root planing; Device: Fotosan 630, CMS Dental, Copenhagen, Denmark

Study type: Interventional

Funder types: Other

Identifiers

NCT02666573

R-221-000-044-597

Details and patient eligibility

About

27 subjects on SPT, each with at least two residual pockets ≥5mm, were recruited for this randomised, split-mouth controlled trial, providing a total of 72 sites. At baseline, probing pocket depth (PPD), recession, clinical attachment level (CAL), plaque and bleeding on probing (BOP) of all sites were examined. Gingival crevicular fluid (GCF) were collected to determine level of cytokines IL-1β, -6, -8, TNF-α and MMP-8 via ELISA. Control sites received subgingival instrumentation and rubber cup polishing with pumice. In addition test sites received a single application of PDT using Fotosan® and photosensitizer consisting of toludine blue O solution. The subjects were recalled three and six months later and re-examined. Site level analysis was performed.

Enrollment: 27 patients

Sex: All

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

1. Good general health with no systemic diseases causing manifestation of periodontal diseases
2. Age ≥ 21 years
3. History of chronic periodontitis
4. At least two residual PPD ≥ 5 mm with or without bleeding on probing
5. Compliant with recalls, i.e. last SPT visit at most 6 months before start of trial
6. Able to give written informed consent

Exclusion criteria

1. Pregnant or lactating females
2. Local or systemic antibiotics intake in the past 3 months
3. Systemic conditions which could affect progression of periodontitis
4. Long term use of NSAIDs or immunosuppressive medications
5. Participation in other clinical trials

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Factorial Assignment

Masking: None (Open label)

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27 participants in 2 patient groups

Photodynamic therapy protocol

Experimental group

Description:

In addition to scaling and root debridement, test sites received PDT according to manufacturer's instructions.

Treatment:

Device: Fotosan 630, CMS Dental, Copenhagen, Denmark

SRP

Other group

Description:

Scaling and root debridement of the residual pockets were performed using ultrasonic device and hand curettes until root surfaces felt hard and smooth. The sites were then polished using rubber cup and prophylaxis paste.

Treatment:

Other: Scaling and root planing