PhotoDynamic Therapy for Line Infection Prevention (PLIP): Pilot Study on Healthy Volunteers.

Mass General Brigham

Status: Completed

Conditions: Light; Therapy, Complications

Treatments: Procedure: Methylene blue and light treatment

Study type: Interventional

Funder types: Other

Identifiers

NCT01981460

2012P-002692

Details and patient eligibility

About

We are evaluating the effect of methylene blue and visible light activation on the microbiome of the skin.

Full description

Antiseptics are routinely utilized to prevent infections of vascular catheters. We are evaluating the addition of methylene blue and light activation on skin to determine whether this inexpensive and non-toxic treatment can decrease skin pathogens and prevent blood stream infections of long-term vascular catheters. This is a pilot study of normal volunteers to determine the effect on the microbiome of the addition of methylene blue and light activation on antiseptic-treated skin.

Enrollment: 10 patients

Sex: All

Ages: 21 to 60 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Normal individuals without skin problems

Exclusion criteria

• Smokers
• Diabetics
• Atopic dermatitis
• G-6-PD deficiency
• Eczema
• Other skin conditions
• Allergies to methylene blue or chlorhexadine

Trial design

Primary purpose: Treatment

Allocation: Non-Randomized

Interventional model: Single Group Assignment

Masking: None (Open label)

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10 participants in 2 patient groups

Chloroprep and biopatch

No Intervention group

Description:

Both arms are cleaned with chloroprep and a biopatch is placed on each arm.

Methylene blue and light treatment

Experimental group

Description:

Methylene blue and light treatment for 17 minutes are done twice over 1 week intervals.

Treatment:

Procedure: Methylene blue and light treatment