Photodynamic Therapy in Treatment of Verrucae

Alexandria University

Status: Unknown

Conditions: Verruca Vulgaris

Treatments: Other: saline; Other: methylene blue / IPL; Other: IPL

Study type: Interventional

Funder types: Other

Identifiers

NCT04620785

0106171

Details and patient eligibility

About

To assess the efficacy (clinically and dermoscopically) and safety of photodynamic therapy using intralesional injection of 4% methylene blue solution as a photosensitizer with IPL versus IPL only in treatment of warts.

Full description

This study will be conducted on:

Eighty patients suffering of verruca (male and female) divided randomly into three groups: group A, B&C :

Group A: 30 patients will undergo photodynamic therapy using intralesional 4%methylene blue solution and IPL.

Group B: 30 patients will undergo IPL only. Group C (control group):20 patients will undergo intralesional saline.

Enrollment: 80 estimated patients

Sex: All

Ages: 16+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

1. Age:Above 16 years old.
2. Sex:Both males and female patients.
3. Clinically and dermoscopically documented verruca.
4. No verruca treatment in the last 2 weeks.

Exclusion criteria

1. History of photosensitivity disorder.
2. Pregnant and lactating females.
3. Diseases with risk of koebnerization e.g. Psoriasis and Lichen planus.
4. Anogenital warts.
5. Warts on head and neck.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

---

80 participants in 3 patient groups, including a placebo group

methylene blue/IPL

Experimental group

Description:

will undergo photodynamic therapy using intralesional 4%methylene blue solution ,after a period of 15 minutes the patient will be subjected to IPL session. This will be repeated biweekly until complete clearance of the lesion or a maximum four sessions.

Treatment:

Other: methylene blue / IPL

IPL

Experimental group

Description:

will undergo biweekly IPL sessions only until complete clearance of the lesion or a maximum four sessions.

Treatment:

Other: IPL

saline

Placebo Comparator group

Description:

will undergo intralesional saline.

Treatment:

Other: saline